Osmotic / Saline Laxatives Examples: Lactulose, Magnesium hydroxide, Magnesium citrate, Polyethylene glycol (PEG) Mechanism: Draw water into the intestine soften stool increase motility Uses: Constipation, hepatic encephalopathy (lactulose), bowel prep (PEG) Adverse Effects: Electrolyte imbalance, bloating, diarrhea 3
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r , Quantification of NMDA-induced (50 M) intracellular calcium rises (%F/F 0 ) following bath application of GLP-1 (1 M, n = 20 neurons) or GLP-1MK-801 (1 M, n = 38 neurons)
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Mechanistically, mitochondrial dysfunction plays a significant role in the development of skeletal muscle insulin resistance (101), and models of muscle-specific estrogen deficiency demonstrate aberrant mitochondrial morphology, increased production of reactive oxygen species, and impaired mitochondrial fission dynamics (99)
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